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To test the hypothesis that aripiprazole 20 mg daily will reduce methamphetamine use significantly more than placebo among methamphetamine-dependent individuals, as determined by the proportion of methamphetamine-positive urines in the aripiprazole versus placebo group.

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Gelenberg AJ, Bellinghausen B, Wojcik JD, Falk WE, Sachs GS.

One can use microarray technology to test for hundreds of single nucleotide polymorphisms (SNPs) but, taking into account the difficulties for single gene approaches such as CYP2D6, it is unlikely that very complex pharmacogenetic approaches will reach the clinical market in the next 5-10 years.

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Although the solvent-drop co-grinding method appears as an attractive solvent and energy-saving alternative, more experimental work is required for the optimization of its parameters, which is beyond the scope of the present study.

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Another open-label study in eight individuals with ASDs, aged 5 to 42 years, revealed a 75% response rate with significant improvements in motor restlessness or hyperactivity, social relatedness, affectual reactions, sensory responses, language usage, SIB, aggression, irritability or anger, anxiety, and depression, but no changes in repetitive behaviors.

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