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Only clozapine has been demonstrated to be efficacious and tolerated in double-blind controlled trials.
Remission occurred in 40 (43%) who received aripiprazole and 26 (29%) who received placebo.
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Observational studies suggest that conventional or first-generation antipsychotic agents also may increase mortality in such patients.
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To test the hypothesis that aripiprazole 20 mg daily will reduce methamphetamine use significantly more than placebo among methamphetamine-dependent individuals, as determined by the proportion of methamphetamine-positive urines in the aripiprazole versus placebo group.
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Recently, three 6-week, large-scale, randomized, double-blind, placebo-controlled clinical trials demonstrated clinically meaningful efficacy for aripiprazole as an adjunctive therapy to antidepressants for treating major depressive disorder (MDD).
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Thereby, the response and remission rates after antidepressant monotherapy are approximately 50-70% and 30%, respectively, in routine practice.
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Gelenberg AJ, Bellinghausen B, Wojcik JD, Falk WE, Sachs GS.
One can use microarray technology to test for hundreds of single nucleotide polymorphisms (SNPs) but, taking into account the difficulties for single gene approaches such as CYP2D6, it is unlikely that very complex pharmacogenetic approaches will reach the clinical market in the next 5-10 years.
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Tardive dyskinesia was only reported by 2 of the aripiprazole-treated patients (0.
Although the solvent-drop co-grinding method appears as an attractive solvent and energy-saving alternative, more experimental work is required for the optimization of its parameters, which is beyond the scope of the present study.
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Another open-label study in eight individuals with ASDs, aged 5 to 42 years, revealed a 75% response rate with significant improvements in motor restlessness or hyperactivity, social relatedness, affectual reactions, sensory responses, language usage, SIB, aggression, irritability or anger, anxiety, and depression, but no changes in repetitive behaviors.
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The conditions and duration of treatment with aripiprazole included (in overlapping categories) double-blind, comparative and noncomparative open-label studies, inpatient and outpatient studies, fixed- and flexible-dose studies, and short- and longer-term exposure.
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In addition, tardive dyskinesia (TD) has also been associated with antipsychotic drugs.
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